Some of the drugs that can interact with lovastatin include danazol, niacin, and fibrates. Grapefruitjuiceqbloodlevelsandtheriskofrhabdomyolysis. If concurrent use of lovastatin and danazol is desired, carefully weigh the benefit of lovastatin against the risk of myopathy and rhabdomyolysis. The change most of the time may results in detrimental effect on the patient. May beqat 4wk intervalsto a maximum of 80 mgday immediaterelease or 60 mgday extendedrelease. Date may 14, 2017 author by eric christianson category uncategorized drug interactions is one thing that pharmacists need to be experts at managing. Handbook of fooddrug interactions nutrition assessment. This study is created by ehealthme based on reports of 47 people who take lovastatin and turmeric from food and drug administration fda, and is updated regularly. Lovastatin has a 30% bioavailability with an extensive firstpass effect.
Lovastatin mevacor side effects, dosage, interactions. Lovastatin is a member of the drug class of statins, used for lowering cholesterol hypolipidemic agent in those with hypercholesterolemia and so preventing cardiovascular disease. Lovastatin oral tablet is a statin used to prevent and treat coronary heart disease, and to treat high cholesterol. Clinical implications and therapeutic strategies provides the most detailed, complete source of information available on how commonly used herbs and nutrients interact with medications.
Drugfooddrug herb interaction guide general rules for patients. This is a useful guide to understanding the science behind nutrient drug interactions. Impact of food on effectiveness of a drug a medication has ingredients, just as food does, that allow it to function correctly when taken in order to help the body in some way. In some people with heart disease, that could trigger a heart attack or a stroke. Clinical conundrum gemfibrozil and statins, what to do. Lovastatin lovastatin dose, indications, adverse effects. A drug food interaction is a condition in which the food affects the activity of a drug. Atorvastatin interaction with food, herbs and alcohol. The complex interaction between food, nutrients, and drugs, make it difficult to accurately determine the exact effects of these relationships in the body. Each of these interactions may lead to many complications. Daily multivitamin drug category drug category brief description drug induced nutrient depletions additional suggested supplements for nutritional support dietary supplements that.
Grapefruit juice increases the level of lovastatin in the blood resulting in unwanted side effects like muscle fiber breakdown, kidney failure, muscle and joint pain. The result, we hope, will prove useful to health and forensic professionals as well as medical, pharmacy, nursing and graduate students alike. The following are key points to remember from the american heart association scientific statement on recommendations for management of clinically significant drug drug interactions ddis with statins and select agents used in patients with cardiovascular disease cvd. Drug interaction with any of these substances may enhance or decrease the effect of atorvastatin. Definition of termsdefinition of terms drug nutrient interaction. An example of a side effect are reduced absorption of nutrients, reduced metabolism of the drug, or altered taste of a specific food. Once you begin taking warfarin, maintain a consistent diet and dont suddenly overload on leafy greens.
Although generally quite safe, the statins can be associated with a variety of serious side adverse effects, including myalgia, myopathy, and changes in plasma enzymes of hepatic origin. Its available as a generic drug and as the brandname drug altoprev. Lovastatin is a cholesterollowering medication called a statin prescribed to treat elevated blood cholesterol levels. Lovastatin is a naturally occurring drug found in food such as oyster mushrooms and red yeast rice. Aha statement on drugdrug interactions with statins. Some products that may interact with this drug include. There are 6 disease interactions with lovastatin which include. See what the interactions are and for which people. Lovastatin is the generic form of the brandname drug mevacor, a medication used to lower cholesterol levels when used in combination with diet, weight loss, and exercise, lovastatin may reduce. Fooddrug interactions what you eat and drink can affect the way your medicines work. Nutrient drug interactions focuses on foods, herbals, and their chemical constituents as contributors to human health through control of metabolism, primarily as they relate to chronic disease. Nutrientdrug interactions can occur with both prescription and overthecounter medicine. Antacids take after meals to increase the duration of effect. However, in order to evaluate the clinical relevance of a food drug interaction the impact of food intake on the clinical effect of the drug has to be quantified as well.
Dont learn the hard way which foods can prevent a prescription or overthecounter drug from working, or exacerbate its side effects. It offers indepth understanding of the critical role that such interactions may have on the patients outcome. Handbook of drugnutrient interactions springerlink. Harmful interactions arent limited to competing drugs you ingest. Foods that contain a lot of vitamin k, such as the greens noted on the left, can reduce the drugs ability to thin the blood. This study is created by ehealthme based on reports of 7,286 people who take levothyroxine sodium and simvastatin from food and drug administration fda, and is updated regularly.
Drug interactions are reported among people who take levothyroxine sodium and simvastatin together. The effect produced when a drug and a food or beverage are taken at the same time. It is important to know if you need to avoid any food, herbs, or alcohol when taking atorvastatin. Lovastatin and turmeric drug interactions a study of fda. Mark this risk when a client is taking a drug or medication that can interfere with nutrient intake or use. A food drug interaction may prevent a medicine form working the way it should, cause a side effect from a medicine to get worse or better. With rapidly growing research and technology, medications are more beneficial, and new ones continue to be discovered. Nutrientdrug interactions nutritional disorders merck. On the other hand, drug food nutrient interactions continue to grow with the common use of medications.
There are many dramatic results and problems that may be caused by fooddrug, drug drug, and alcohol food drug. A drug is defined as a substance used in the diagnosis, treatment, or prevention of a disease, or component of a medication. Antibacterials better absorption if taken on an empty stomach one hour before meals or two hours after meals. This table lists common drugs that can affect nutrition status. Drug interactions with lovastatin there are a number of drugs that can potentially cause severe side effects or complications when taken with lovastatin.
There are 12 disease interactions with lovastatin niacin which include. Handbook of drug nutrient interactions, second edition is a comprehensive uptodate text for the total management of patients on drug andor nutrition therapy but also an insight into the recent developments in drug nutrition interactions which will act as a reliable reference for. Although rare, the most serious of these is rhabdomyolysis. New book provides definitive guide to supplement drug interactions the recent release of the landmark textbook herb, nutrient, and drug interactions. There are 300 drug interactions with lovastatin niacin. When the way a medicine works is affected by food and drinks this is called a food drug interaction. The book starts the reader out with some basic concepts of pharmacy, moves on through drug biopharmaceutics, food drug interactions and metabolism. As this emedtv page explains, some of the drug interactions with lovastatin can cause severe side effects and complications, including serious muscle problems. Rather than simply list potential fooddrug interactions, this book provides explanations and gives specific recommendations based on th. Beside the awareness of this type of interactions, food drug interaction studies are critical to evaluate appropriate dosing, timing, and formulation of new drug candidates. With contributions from the fields of pharmacy, dietetics, and medicine, handbook of fooddrug interactions serves as an interdisciplinary guide to the prevention and correction of negative fooddrug interactions. His current medications include lovastatin to lower his cholesterol and an mao inhibitor to treat depression.
The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. Levothyroxine sodium and simvastatin drug interactions a. A healthcare professional should be consulted before taking any drug. When lovastatin is taken with medicines such as protease inhibitors, antifungals, or niacin, your body may metabolize the drugs differently than intended. Lovastatin interaction with food, herbs and alcohol. When administered without food, its bioavailability is reduced by 50%. Developed by practitioners and researchers especially for use in the clinic or pharmacy. The statins are widely used worldwide to reduce risk for cardiovascular events in both the primary and secondary prevention settings. Nutrientdrug interactions and nutritional disorders learn about from the merck manuals medical professional version. With contributions from the fields of pharmacy, dietetics, and medicine, handbook of food drug interactions serves as an interdisciplinary guide to the prevention and correction of negative food drug interactions. Nutrientdrug interactions medications have become an integral part of life for many people. Medicine serves to help people when they are sick, allowing them to live longer and healthier lives. Merck manual please confirm that you are a health care professional.
Drug interactions are reported among people who take lovastatin and turmeric together. Use of prescription or overthecounter drugs or medications shown to interfere with nutrient intake or use, to an extent that nutritional status is compromised. Pocket guide to evaluations of drug interactions frederic j. If the client is taking a drug or medication that isnt on this list, check the food medications interactions book for possible side effects. Rather than simply list potential food drug interactions, this book provides. Madelyn fernstrom, a nutrition and diet expert featured on nbcs today show, and awardwinning neuroscientist and pharmacologist john fernstrom her husband are the authors of a new aarp book, dont eat this if. The most important interactions are those associated with a high risk of treatment failure arising from a significantly reduced bioavailability in the fed state.
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